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GSK 690
CAS No. 2101305-84-2
GSK 690( GSK690 )
Catalog No. M13334 CAS No. 2101305-84-2
GSK 690 is an irreversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1) with IC50 of 77 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGSK 690
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NoteResearch use only, not for human use.
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Brief DescriptionGSK 690 is an irreversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1) with IC50 of 77 uM.
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DescriptionGSK 690 is an irreversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1) with IC50 of 77 uM.
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In VitroGSK690 (1-10μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells).GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1?μM GSK690 for RD cells) and 10?μM GSK690 for RH30 cells.GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest .
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In Vivo——
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SynonymsGSK690
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorHistone Demethylase
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Research Area——
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Indication——
Chemical Information
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CAS Number2101305-84-2
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Formula Weight369.468
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Molecular FormulaC24H23N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESN#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1
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Chemical Name(R)-4-[5-(Pyrrolidin-3-ylmethoxy)-2-p-tolyl-pyridin-3-yl]-benzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mould DP, et al. J Med Chem. 2017 Sep 11. doi: 10.1021/acs.jmedchem.7b00462.
2. Mould DP, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4755-4759.
3. McGrath JP, et al. Cancer Res. 2016 Apr 1;76(7):1975-88.
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